2024 The lc3 interactome at a glance

The lc3 interactome at a glance

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SpletIn higher eukaryotes, the Atg8 family comprises six members known as the light chain 3 (LC3) or γ-aminobutyric acid (GABA)-receptor-associated protein (GABARAP) proteins. Considerable effort during the last 15 years to decipher the molecular mechanisms that govern autophagy has significantly advanced our understanding of the functioning of ... SpletThe LC3 interactome at a glance. scientific article published on 17 December 2013. Statements. instance of. scholarly article. 1 reference. stated in. Europe PubMed Central. PubMed ID. 24345374. retrieved. 30 August 2024.

Relationship Between Redox Status and Cell Fate in Immunity and ...

SpletSci-Hub The LC3 interactome at a glance. Journal of Cell Science, 127 (1), 3–9 10.1242/jcs.140426 sci hub to open science ↓ save Wild, P., McEwan, D. G., & Dikic, I. … Splet30. jan. 2012 · Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane reorganization … react navigation stack npm

The LC3 interactome at a glance. - Abstract - Europe PMC

Splet25. okt. 2024 · Atg12 and LC3 are regulated by an ubiquitin-like conjugation system. Atg12 is covalently conjugated to Atg5 by the E1-like enzyme Atg7 and the E2-like enzyme Atg10, sequentially binding to Atg16L1 to form the Atg12–Atg5–Atg16L1 complex. SpletThe results demonstrate that inhibition of LIR of a single autophagy receptor is insufficient to sensitize the cells to cytarabine, while simultaneous inhibition of three LIR motifs in three distinct SARs reduces the IC50 of the chemotherapeutic. Short linear motifs (SLiMs) located in disordered regions of multidomain proteins are important for the organization of … Splet12. nov. 2024 · Monitoring LC3 or GABARAP subfamily-positive autophagic membranes using RavZ-based probes modified by replacement of LIR motifs with those selective for members of the LC3 or GABARAP subfamily react navigation usenavigation

Lysosomal dysfunction and autophagy blockade contribute to IMB …

Splet17. dec. 2013 · Central to this pathway is a set of key autophagy proteins, including the ubiquitin-like modifier Atg8, that orchestrate autophagosome initiation and biogenesis. In higher eukaryotes, the Atg8 family comprises six members known as the light chain 3 (LC3) or γ-aminobutyric acid (GABA)-receptor-associated protein (GABARAP) proteins. Splet20. mar. 2024 · Tanida I, Ueno T, Kominami E (2004) LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 36: 2503 – 2518 Crossref CAS PubMed Web of Science® Google Scholar; Wild P, McEwan DG, Dikic I (2014) The LC3 interactome at a glance. J Cell Sci 127: 3 – 9 Crossref CAS PubMed Web of Science® Google Scholar react navigation stack grouphttp://elm.eu.org/elms/LIG_LIR_LC3C_4.html react navigation v5

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The lc3 interactome at a glance

SpletThe LC3 interactome at a glance J Cell Science 2014 Veröffentlichung anzeigen. Crystal structures of the free and ligand-bound FK1-FK2 domain segment of FKBP52 reveal a flexible inter-domain hinge J Mol Biol 2013 Veröffentlichung anzeigen. Structural basis for phosphorylation-triggered autophagic clearance of Salmonella ... Splet04. sep. 2013 · Should LC3 species interact with p62, they would be incorporated into p62 punctae. As such, we can observe these interactions in cells utilizing fluorescence microscopy. To accomplish cleavage of pro-LC3, a protein complex must form between a substrate (pro-LC3) and enzyme (Atg4B).

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Splet09. okt. 2024 · LC3 (Light Chain 3) is a key player of autophagy, a major stress-responsive proteolysis pathway promoting cellular homeostasis. It coordinates the formation and maturation of autophagosomes and recruits cargo to be further degraded upon autophagosome-lysosome fusion. Splet12. apr. 2024 · 1 INTRODUCTION. Gigaxonin is a ubiquitously expressed protein encoded by the GAN gene located on human chromosome 16q24.1. 1, 2 The lack or loss of function of gigaxonin causes giant axonal neuropathy (GAN), an autosomal recessive disorder. The GAN gene has more than 50 distinct loss of function mutations that cause the disorder. 3 …

SpletSci-Hub The LC3 interactome at a glance. Journal of Cell Science, 127 (1), 3–9 10.1242/jcs.140426 sci hub to open science ↓ save Wild, P., McEwan, D. G., & Dikic, I. (2013). The LC3 interactome at a glance. Journal of Cell Science, 127 (1), 3–9. doi:10.1242/jcs.140426 10.1242/jcs.140426 Splet07. dec. 2024 · Rubicon (Rubcn) was initially identified as a component of the Class III PI3K complex and a negative regulator of canonical autophagy and endosomal trafficking.However, Rubicon has attracted the most notoriety because of its critical role in LC3-associated phagocytosis (LAP), a form of noncanonical autophagy that utilizes …

Splet23. mar. 2024 · LC3 protein is the basic component of the inner and outer membrane of autophagy, so it can be used as a suitable marker in autophagy . ... “The LC3 interactome at a glance,” Journal of Cell Science, vol. 127, no. 1, pp. 3–9, 2014. View at: Publisher Site Google Scholar. Splet17. dec. 2013 · The LC3 interactome at a glance Authors: Philipp Wild David G McEwan Beatson Institute for Cancer Research Ivan Dikic Goethe-Universität Frankfurt am Main Abstract Continuous synthesis of all...

Spletmolecular weight of LC3-II is larger than that of LC3-I due to the addition of PE, LC3-II migrates faster than LC3-I in SDS-PAGE probably because of its extreme hydropho-bicity. LC3 conversion from LC3-I to LC3-II therefore represents PE-conjugation, not processing of LC3. LC3-I is usually detected on a gel at a molecular mass around 16 kD, react navigator stackSplet摘要目的:观察饥饿及雨蛙素诱导的大鼠胰腺腺泡细胞AR42J中自噬基因LC3及beclin-1表达的变化,初步探讨吞噬(autophagy)在急性胰腺炎中的作用。方法:选择体外培养的生长状态良好的大鼠胰腺腺泡AR42J细胞,随机分为3组,饥饿组(N=10),雨蛙素处理组(N=10),空白对照 … react navigation with reduxSpletIn higher eukaryotes, the Atg8 family comprises six members known as the light chain 3 (LC3) or c-aminobutyric acid (GABA)-receptorassociated protein (GABARAP) proteins. Considerable effort during the last 15 years to decipher the molecular mechanisms that govern autophagy has significantly advanced our understanding of the functioning of this ... how to start your own cosmetology businessSplet24. sep. 2010 · Autophagosome membrane elongation involves two ubiquitin-like conjugation systems: LC3 (mammalian Atg8)-PE (phophatidylethanolamine) conjugation and Atg12–Atg5 conjugation. 60 After proteolytic... react navigation top barSpletArthritis Rheum 43: misfolded proteins prevents ER-derived oxidative stress 2230–2239, 2000. and cell death. Mol Cell 15: 767–776, 2004. 78. Jin SM and Youle RJ. PINK1- and Parkin-mediated mi- 62. He C and Levine B. The Beclin 1 interactome. Curr Opin tophagy at a glance. J Cell Sci 125: 795–799, 2012. react navigation with paramsSpletMany of these adaptor proteins contain an LC3-interacting region (LIR) that mediates binding to Atg8 and Atg8-related proteins. These LIR:Atg8/LC3/GABARAP interactions are essential for cellular cell homeostasis as well as the control of intra- … how to start your own country wikihowSplet18. feb. 2024 · All cells and intracellular components are remodeled and recycled in order to replace the old and damaged cells. Autophagy is a process by which damaged, and unwanted cells are degraded in the lysosomes. There are three different types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy. … react navigator is not defined