Myc lethal
Web3 feb. 2024 · Overexpression of N-MYC causes replication stress and DNA damage by the ectopic replication-fork firing, which results in remarkably higher sensitivity of N-MYC … WebExpression of MYC family members and lineage-related transcription factors ASCL1, NEUROD1, and POU2F3 (and, ... (SCLC) is a rapidly lethal disease with few therapeutic options.
Myc lethal
Did you know?
Web4 mrt. 2024 · Synthetic lethal screening, which exploits the combination of mutations that result in cell death, is a promising method for identifying novel drug targets. This method provides a new avenue for targeting “undruggable” proteins, such as c-Myc. Here, we revisit current methods used to target c-Myc and discuss the important functional nodes related … WebWe exploit the increased MYC expression found in triple-negative breast cancers by using a synthetic-lethal approach dependent on cyclin-dependent kinase (CDK) inhibition. CDK inhibition effectively induced tumor regression in triple-negative tumor xenografts.
Web20 jan. 2024 · c-Myc protein has been considered to be “undruggable” due to its helix-loop-helix topology lacking druggable domains and nuclear localization within cancer cells, … Web13 apr. 2024 · Here, we determined that, although OTX015 monotherapy exerted modest lethal effects, co-treatment with SNDX-50469 and OTX015 induced synergistic lethal effects in the CRISPR-edited MOLM13 cells ...
WebThe deregulation of the MYC family of oncogenes, including c-MYC, MYCN and MYCL occurs in many types of cancers, and is frequently associated with a poor prognosis. The majority of functional studies have focused on c-MYC due to its broad expression profile in human cancers. The existence of highly conserved functional domains between MYCN … WebMechanisms of MYC Synthetic Lethality in Cancer. Two broad groups of vulnerabilities in MYC-driven tumours have been identified based on the oncogenic properties of MYC – …
Web3 sep. 2024 · For example, patients with MYC deregulation can be screen with a panel of SSOs against synthetic lethal targets of MYC, while patients with mutations in CTNNB1, a frequent genetic alteration in HCC, can be screened with a panel of SSOs targeting the β-catenin pathway. 90 Upon identification of an effective combination, patients can be …
Web13 dec. 2014 · MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC in cancer has been challenging thus far. Synthetic lethality provides an opportunity for therapeutic intervention of MYC-driven cancers. A pooled kinase shRNA library screen was performed and next … sick wt150-p430sick wt150-p162Web20 mrt. 2024 · NMT is a promising target in cancer, but a mechanistic rationale for targeted therapy remains poorly defined. Here, large-scale cancer cell line screens against a … the pie shelfWebMYC contributes to poor prognosis in aggressive lymphoma. MYC function is reduced by inhibition of chromatin readers of the bromodomain and extra-terminal repeat (BET) … the pie shapeWebOverexpressed Myc primes cells to the lethal effect of VX-680 by promoting illegal DNA synthesis and mitosis in the absence of cytokinesis [4,6]. This Myc activity allows pulsed treatments with VX-680 to achieve an enduring anticancer effect by eliciting delayed lethality without the requirement of continuous exposure to the drug. sick wraps for carsWebThe MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC triggers selective gene expression amplification to promote cell growth and proliferation. the pie shell facebookWeb24 mrt. 2024 · Here, we conducted a high-content screen for compounds that are synthetic lethal to elevated MYC using a small-molecule library to identify compounds that are closely related to, or are themselves, regulatory-approved drugs. The screen identified dimethylfasudil, a potent and reversible inhibitor of Rho-associated kinases, ROCK1 and … sick wt18 3p430