Infusion rate of phenytoin
Webb1 nov. 2011 · Because of potential adverse reactions related to high serum phenytoin concentrations and rapid infusion rates (e.g., hypotension, ataxia, nausea, vomiting, apnea, nystagmus), 12 the patient’s age, the baseline presence of atrial fibrillation and ataxia, and the fact that seizures were not being treated, the clinical pharmacist … WebbMost patients (22/28, 79%) who received an IV infusion of FOS had status epilepticus (SE). The presence of SE was significantly associated with the development of hypotension (P=.026); hypotension occurred in half of the patients with SE, but did not occur in six patients without SE.
Infusion rate of phenytoin
Did you know?
ORAL ADMINISTRATION: Extended-Release Capsules: 1. Initial dose (phenytoin-naive): 100 mg orally 3 times a day 2. Adjust dose as needed 3. Maintenance dose: 100 mg orally 3 or 4 times a day; increases to 600 mg 3 times a day may be needed for some patients 4. For patients with established seizure control at … Visa mer LOADING DOSE: 10 to 15 mg/kg by slow IV infusion, not to exceed 50 mg/min MAINTENANCE DOSE: 100 mg orally or IV every 6 to 8 hours Comments: 1. Electrocardiogram and blood pressure should be monitored … Visa mer LOADING DOSE: 15 to 20 mg/kg IV at a rate not to exceed 1 to 3 mg/kg/min or 50 mg/min, whichever is slower MAINTENANCE … Visa mer IV Use should be reserved for use when ORAL Administration is not possible ORAL ADMINISTRATION: Extended-Release Capsules: 1. Initial dose (phenytoin-naive): 100 mg orally 3 times … Visa mer IV Use should be reserved for use when ORAL Administration is not possible ORAL ADMINISTRATION: Extended-Release Capsules; Chewable Tablets; Oral Suspension: 1. Initial dose (phenytoin-naive): 5 mg/kg/day … Visa mer WebbPhenytoin IV administration. Give phenytoin over 30-40 minutes (rate <50mg/minute). In patients who are elderly, or have pre-existing cardiac disease, give phenytoin over 60 …
Webb1 feb. 1991 · Twelve of these 14 described the pain as toler- able, but in two of the 14 the rate of phenytoin infusion had to be de- creased to 25 mg/min because of their pain. Three of 16 group 2 patients devel- oped adverse cardiovascular side ef- fects during phenytoin infusion. These effects are summarized in Ta- ble 2. Webb8 dec. 2015 · The infusion rate of phenytoin if it was given as antiarrhythmic drug was between 50 and 350 mg/min, and the total dose was 250–350 mg. For the use in epilepsy, the phenytoin dose was higher (15–25 mg/kg), however, the infusion rate was slower (20–100 mg/min) ...
Webb24 aug. 2012 · Pharmacokinetic parameters of phenytoin, such as total clearance and central and peripheral volume of distribution were influenced by body weight. The dose simulations are as follows. In adult patients, the optimal dose and infusion rate of phenytoin for achieving the therapeutic range was 22.5 mg/kg and 3 mg/kg/min … Webb17 okt. 1977 · Recommended infusion rate for adults: 40-50 mg/min. Elderly (>65): Recommended infusion rate: 20-25 mg/min. Oral loading: Give in 3 to 4 divided doses at q2h intervals. (Divided doses increase …
Webb21 okt. 2024 · The rate of administration for IV phenytoin sodium injection should be no greater than 50 mg per minute in adults and 1 to 3 mg/kg/min (or 50 mg per minute, …
Webb1 sep. 2003 · The doses of i.v. phenytoin were between 18 and 20 mg/kg/dose for all loading doses and between 3 and 6 mg/kg/dose for all maintenance doses; all … sartori whiskeyWebb9 feb. 2024 · red skin lesions, often with a purple center. red, irritated eyes. redness and swelling of the gums. slow or irregular heartbeat. sore throat. sores, ulcers, or white spots on the lips or in the mouth. stomach pain. swollen, painful, or tender lymph glands in the neck, armpit, or groin. unusual bleeding or bruising. sarto tailoring liverpoolWebbcomplex, and when used in an emergency setting (eg, status epilepticus), differences in rate of availability of phenytoin could be critical. Studies have therefore empirically determined an infusion rate for CEREBYX that gives a rate and extent of phenytoin systemic availability similar to that of a 50 mg/min phenytoin sodium infusion. sarto thomasWebb15 jan. 2024 · In the intravenous form, the main toxicity is believed to be from its parenteral vehicle: propylene glycol. Propylene glycol is a cardiac depressant, and rapid infusions can lead to bradycardia, hypotension, and asystole. Care must be taken so that intravenous formulations of phenytoin are not administered at a rate faster than 50 mg … sarto themeWebb1 maj 1997 · Their research delineated minimal maternal and fetal side effects when phenytoin is infused at a rate of less than 50 mg per minute (Ryan et al., 1989, Slater et al., 1987). Studies support a rate of infusion of 25–50 mg per minute because the risk of hypotension increases with rates exceeding 50 mg per minute ( Friedman et al., 1993 , … sartorius wittlichWebbA total dose of 18 mg/kg was administered as a solution of 500 mg phenytoin in 50 mL normal saline using a constant infusion pump. The initial delivery rate was 40 mg/min. Cardiac rhythm was monitored by telemetry, and rhythm strips and vital signs were obtained every 15 minutes during infusion. sartory definitionWebbAn infusion rate of 50 mg/min was reported to be safe for young patients. For old patients and patients with a cardiovascular co-morbidity, a slower infusion rate was … sartorius tangential flow filtration system