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Ewsr1 atf1

WebAug 20, 2024 · EWSR1 - ATF1 fusion has been characterized as a consistent finding in CCC, with breakpoints described between EWSR1 exon 11 and ATF1 exon 3. So far, over 100 cases of CCC harboring EWSR1 rearrangement arising from salivary gland of the oral cavity have been reported. WebDec 19, 2007 · Either FUS-ATF1 or EWSR1-ATF1 have been detected in the few cases published, pointing to the interchangeable role of FUS and EWSR1 in this entity. EWSR1-ATF1 also represents the most frequent genetic alteration in clear cell sarcoma, suggesting the existence of a molecular homology between these two histotypes.

Primary lung hyalinizing clear cell carcinoma: a diagnostic …

WebMar 29, 2024 · a breakpoint in the EWSR1-ATF1 fusion to be the same as that reported in HCCC. Established CCOC-T cells grew extremely slowly, but the cells showed highly … WebJan 31, 2024 · RT–PCR reliably identified the EWSR1-WT1 transcript in 2 of 3 FISH-negative cases. High FISH positivity rates were also documented in CCS (87.9%) and CCSLGT (80.0%). A fusion transcript involving... if 赤文字 https://luney.net

EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of

WebEWSR1-ATF1 rearrangement in another case, which had been already detected by two-color FISH. FISH results are summa-rizedinTable1. RT-PCR. RT-PCRforFUS-ATF1,FUS … WebMar 27, 2024 · In primary tumors of the lung, EWSR1-ATF1 gene fusions have been well-characterized in clear cell sarcoma (CCS) [ 19 ], malignant mesothelioma (MM) [ 20 ], and angiomatoid fibrous histiocytoma (AFH) [ 21 ]. In our case, morphology and immunophenotype did not support the diagnosis of AFH. EWSR1-ATF1 binding sites in CCS are distinct from endogenous wild type ATF1. In order to study EWSR1-ATF1 function in CCS, we first identified EWSR1-ATF1 binding sites in two well-established CCS ... if 返回数组

EWSR1—The Most Common Rearranged Gene in Soft Tissue …

Category:病理视角 FUS-CREB定义了一种独特的恶性上皮样肿瘤_医学界-助 …

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Ewsr1 atf1

Clear Cell Sarcoma: Diagnosis, Treatment and Surveillance

WebUnlike melanoma, clear cell sarcoma harbors either a t(12;22)(q13;q12) recurrent translocation, resulting in an EWSR1/ATF1 chimeric gene, or less commonly a … WebEWSR1-ATF1 rearrangement in another case, which had been already detected by two-color FISH. FISH results are summa-rizedinTable1. RT-PCR. RT-PCRforFUS-ATF1,FUS-CREB1,EWSR1-ATF1,

Ewsr1 atf1

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WebConversely, EWSR1-ATF1 depletion results in a marked reconfiguration of 3D connectivity, including the emergence of regulatory circuits that … WebEWSR1-ATF1).29,30 Interestingly, the recently described entity “adamantinoma- like Ewing sarcoma” is characterized by EWSR1-FLI1 fusions; it is unclear whether this entity truly represents a true variant of Ewing sarcoma or is a

WebJul 12, 2024 · Herein, we report an interesting case of CCC harboring three EWSR1-ATF1 translocations: EWSR1 exon 8-ATF1 exon 4, EWSR1 exon 7-ATF1 exon 4, and EWSR1 exon 7-ATF1 exon 5. This case indicates the possibility of independent EWSR1-ATF1 gene translocations, and could provide insight into CCC tumorgenesis. Introduction

WebMar 21, 2024 · EWSR1 (EWS RNA Binding Protein 1) is a Protein Coding gene. Diseases associated with EWSR1 include Ewing Sarcoma and Desmoplastic Small Round Cell … WebJan 18, 2013 · EWSR1/ATF1 t(12;22)(q13;q12) ATF1 is a transcription factor (c-AMP dependent) belonging to leucine-zipper proteins. The ability of this gene to produce a fusion transcript with EWS has been demonstrated in clear-cell sarcoma, defined in the past as malignant melanoma of soft parts (MMSP) [57, 58] More recently, EWS/ATF-1 has been …

WebEWSR1-ATF1 Fusion is present in 0.09% of AACR GENIE cases, with clear cell sarcoma of soft tissue, sarcoma, NOS, clear cell odontogenic carcinoma, salivary carcinoma, NOS, …

WebMar 9, 2024 · EWSR1-ATF1 translocation has been reported in other tumors, such as angiomatoid fibrous histiocytoma, hyalinizing clear cell carcinoma, and clear cell … if 跳转WebApr 13, 2024 · 两例ewsr1-crem融合阳性的研究病例（病例#5和12，红线）聚集在一起，远离其他12例ewsr2-creb融合肿瘤：3例透明细胞肉瘤（2例ewsr1-atf1，1例ewsr-1 … istericoWebClear cell sarcoma-like gastrointestinal tumor (also termed gastrointestinal neuroectodermal tumor ): The neoplastic cells in these tumors express an EWSR1:ATF1 or EWSR1:CREB1 fusion genes in >50% or ~25% of cases, respectively. [1] [23] isteria bollasWebApr 10, 2024 · 50.EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma. EWSR1-ATF1依赖性三维连接调控透明细胞肉瘤的致癌和分化程序。 51.Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease. if 返回空值WebJun 15, 2024 · Whereas EWSR1-ATF1 and EWSR1-CREB are the two most characterized fusions, EWSR1-CREM is less well studied . Whether or not AFH (including its myxoid variant), PPMS, so-called mesothelioma, and EWSR1-CREM undifferentiated sarcoma are a spectrum of one tumor type will yield further studies in the future. is terezin worth visitingWebApr 13, 2024 · 两例ewsr1-crem融合阳性的研究病例（病例#5和12，红线）聚集在一起，远离其他12例ewsr2-creb融合肿瘤：3例透明细胞肉瘤（2例ewsr1-atf1，1例ewsr-1-creb1，绿色），2例胃肠道透明细胞肉瘤，1个黏液样间充质瘤（ewsr1-crem，紫色）和1个透明透明细胞癌（ewsr1-atf1，橙色）。 if 近似一致WebEWSR1-CREB1 and EWSR1-ATF1 are gene fusions of which one or both have now been consistently described in 5 histopathologically and behaviorally diverse neoplasms: … if 返回值