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Cisplatin renal injury

WebApr 1, 2024 · However, cisplatin medication has many side effects, such as ototoxicity, neurotoxicity, nephrotoxicity, nausea, and vomiting [ 35, 97, 98, 99 ]. Nephrotoxicity occurs because cisplatin is taken up by the proximal tubular cells and can concentrate up to five times more than the cisplatin in the serum [ 35, 97 ]. WebIntroduction. Cisplatin is an extensively used chemotherapeutic drug for various types of human cancer. However, 20–35% of patients are diagnosed with renal dysfunction after …

Loss of renal tubular G9a benefits acute kidney injury by lowering ...

WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in … WebMar 20, 2024 · Background The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to … hamburg hafencity run https://luney.net

Frontiers Protective Effect of Mannitol on Cisplatin-Induced ...

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebSep 1, 2024 · These results suggest that ABs, through iPGE 2-dependent mechanisms, might have a relevant role in the natural history of cisplatin-induced acute kidney failure … WebOct 22, 2024 · We hypothesized that cisplatin, an anticancer drug that generally causes DNA damage and cell death in rapidly proliferating cells, exacerbates DNA damage in regenerative proliferating renal... hamburg hafen queen mary 2

Natural products: potential treatments for cisplatin …

Category:PSTPIP2 inhibits cisplatin-induced acute kidney injury by

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Cisplatin renal injury

Macrophages in Kidney Injury, Inflammation, and …

WebJul 7, 2016 · This study presents data on renal outcomes across multiple tumor types in 821 adults. We report on incidence of AKI, initial and long-term changes in eGFR after … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …

Cisplatin renal injury

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WebFeb 1, 2024 · Cisplatin-Induced Kidney Injury: Delivering the Goods 2024 Feb;33 (2):255-256. doi: 10.1681/ASN.2024121591. Authors Joshua N Curry 1 , James A McCormick 2 … WebMay 1, 2015 · Cisplatin causes direct necrosis and apoptosis of proximal tubule cells but also induces a series of inflammatory changes that mediate kidney injury. In vitro cisplatin induced enhanced expression of TLRs …

WebAug 6, 2014 · A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often … WebAug 1, 2014 · Purpose: Tubular secretion of cisplatin is abolished in mice deficient for the organic cation transporters Oct1 and Oct2 (Oct1/2(-/-)mice), and these animals are …

WebMay 5, 2024 · Here, we found that bisdemethoxycurcumin (BDMC), a natural compound, can significantly attenuates cisplatin-induced apoptosis of renal tubular epithelial cells in … WebJul 31, 2014 · Although the severity of cisplatin-induced nephrotoxicity is reduced following genetic or pharmacologic knockout of Oct1 and Oct2, renal tubular damage is not completely abolished. This suggests the existence of a secondary pathway that contributes, independently of Oct1/Oct2-mediated renal tubular drug uptake, to cisplatin-induced …

WebFeb 5, 2010 · It is the urinary concentrations of furosemide that determine its diuretic effect. The severity of acute kidney injury has a significant effect on the diuretic response to furosemide; a good ‘urinary response’ may be considered as a ‘proxy’ for having some residual renal function.

hamburg hafen webcam liveWebApr 3, 2024 · As a result, renal injury is the most serious adverse effect restricting the application of cisplatin [ 4 ]. The prevalence of CP-induced acute kidney injury (CP-AKI) is approximately 31% to 68% in patients using cisplatin [ 5 ]. CP-AKI is characterized by tubular damage and acute renal dysfunction [ 6 ]. hamburg hafen port authorityWebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in … burning bush hedge in winterWebMar 9, 2024 · Renal TNF-α expression is increased in a cisplatin-induced nephrotoxic mouse, and cisplatin-induced renal insufficiency and injury can be significantly … hamburg hafencity universitätWebMar 29, 2024 · Cisplatin-Induced Acute Kidney Injury: Role of the Immune System . Inflammatory pathways have been linked to major pathophysiological mechanisms … hamburg half marathonWebDec 16, 2024 · Cisplatin induces acute ischemic injury, resulting in decreased renal medullary blood flow ( 24) and renal tubular cell damage ( 25 ). Meanwhile, cisplatin can block calcium ion channels to reduce COX-2 and prostaglandin, cause vasoconstriction, and eventually lead to aggravation of hypoxia ( 26 ). hamburg halloween paradeWebThe cisplatin-treated rats exhibited acute structural damage characterized by tubular necrosis, swelling and tubular dilation, extensive epithelial vacuolization, and hyaline casts in renal... hamburg halbmarathon 2023